Protein Structure Prediction and Molecular Forces
نویسنده
چکیده
Our ability to predict protein structures from amino acid sequences depends on our understanding of molecular forces. The same applies to the validation of protein structures determined in the laboratory. The protein structures available in the public domain contain a number of deficiencies and inconsistencies. As long as we are unable to recognize and correct such errors on a regular basis we cannot completely trust the experimental results and we cannot have any confidence in predicted structures. Here we investigate the theory of intermolecular forces from the perspective of protein structure theory, comment on the fundamental ideas involved, discuss the difficulties encountered, and we provide examples to illustrate the current state of affairs in protein structure validation and prediction. Forces in Protein Structures 3
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